secure has 21 distinct synonyms spread across 8 of its 11 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is insecure.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
free from fear or doubt; easy in mind
“he was secure that nothing will be held against him”
free from danger or risk
“secure from harm”
not likely to fail or give way
“the lock was secure”
Synonyms, antonyms and the broader and narrower relations for secure come from Princeton University’s WordNet. Full sources and licences.
immune to attack; incapable of being tampered with
“an impregnable fortress”