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lock has 16 distinct synonyms spread across 7 of its 15 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is unlock.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
hold fast (in a certain state)
“He was locked in a laughing fit”
pass by means through a lock in a waterway
build locks in order to facilitate the navigation of vessels
a fastener fitted to a door or drawer to keep it firmly closed
Synonyms, antonyms and the broader and narrower relations for lock come from Princeton University’s WordNet. Full sources and licences.
a mechanism that detonates the charge of a gun
enclosure consisting of a section of canal that can be closed to control the water level; used to raise or lower vessels that pass through it
a restraint incorporated into the ignition switch to prevent the use of a vehicle by persons who do not have the key
any wrestling hold in which some part of the opponent's body is twisted or pressured