hand has 15 distinct synonyms spread across 7 of its 16 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a hired laborer on a farm or ranch
“the hired hand fixed the railing”
something written by hand
“she recognized his handwriting”
ability
“he wanted to try his hand at singing”
a position given by its location to the side of an object
“objections were voiced on every hand”
the cards held in a card game by a given player at any given time
“I didn't hold a good hand all evening”
one of two sides of an issue
“on the one hand..., but on the other hand...”
a rotating pointer on the face of a timepiece
“the big hand counts the minutes”
a unit of length equal to 4 inches; used in measuring horses
“the horse stood 20 hands”
a member of the crew of a ship
“all hands on deck”
a card player in a game of bridge
“we need a 4th hand for bridge”
a round of applause to signify approval
“give the little lady a great big hand”
terminal part of the forelimb in certain vertebrates (e.g. apes or kangaroos)
“the kangaroo's forearms seem undeveloped but the powerful five-fingered hands are skilled at feinting and clouting”
Synonyms, antonyms and the broader and narrower relations for hand come from Princeton University’s WordNet. Full sources and licences.
guide or conduct or usher somewhere
“hand the elderly lady into the taxi”