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extremity has 2 distinct synonyms spread across 1 of its 5 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
an extreme condition or state (especially of adversity or disease)
the greatest or utmost degree
“the extremity of despair”
the outermost or farthest region or point
that part of a limb that is farthest from the torso
Synonyms, antonyms and the broader and narrower relations for extremity come from Princeton University’s WordNet. Full sources and licences.