ease has 14 distinct synonyms spread across 8 of its 9 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is difficulty.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
freedom from difficulty or hardship or effort
“he rose through the ranks with apparent ease”
a freedom from financial difficulty that promotes a comfortable state
“a life of luxury and ease”
freedom from constraint or embarrassment
“I am never at ease with strangers”
freedom from activity (work or strain or responsibility)
“took his repose by the swimming pool”
move gently or carefully
“He eased himself into the chair”
Synonyms, antonyms and the broader and narrower relations for ease come from Princeton University’s WordNet. Full sources and licences.
make easier
“you could facilitate the process by sharing your knowledge”