comfort has 9 distinct synonyms spread across 6 of its 9 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is discomfort.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a state of being relaxed and feeling no pain
“he is a man who enjoys his comfort”
a feeling of freedom from worry or disappointment
the act of consoling; giving relief in affliction
“his presence was a consolation to her”
a freedom from financial difficulty that promotes a comfortable state
“a life of luxury and ease”
satisfaction or physical well-being provided by a person or thing
“his friendship was a comfort”
assistance, such as that provided to an enemy or to a known criminal
“it gave comfort to the enemy”
Synonyms, antonyms and the broader and narrower relations for comfort come from Princeton University’s WordNet. Full sources and licences.