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clean up has 6 distinct synonyms spread across 1 of its 4 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
Synonyms, antonyms and the broader and narrower relations for clean up come from Princeton University’s WordNet. Full sources and licences.
make a big profit; often in a short period of time
“The investor really cleaned up when the stock market went up”
make oneself clean, presentable or neat
“Clean up before you go to the party”