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be-all and end-all has 1 distinct synonym spread across 1 of its 1 sense. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
the essential factor; the all-important element; the supreme aim
“profit is the be-all and end-all of business”
Synonyms, antonyms and the broader and narrower relations for be-all and end-all come from Princeton University’s WordNet. Full sources and licences.