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Feature checklists make every tool look equivalent. This table leads with the three things that actually differ — what it costs you before it works, whether your files leave your device, and where the free version stops.
| Drugs.com Interaction Checkerdrugs.com | FoodData Centralfdc.nal.usda.gov | MedlinePlusmedlineplus.gov | ExRx.netexrx.net | |
|---|---|---|---|---|
| What it does | Lists the interactions between the medicines, supplements and alcohol you enter | The USDA's laboratory-measured nutrient data for tens of thousands of foods | Plain-language health information from the US National Library of Medicine | An exercise library that names the muscles each movement actually works |
| What it costs you | No sign-upWorks the moment the page loads. No account, no email, no trial. | No sign-upWorks the moment the page loads. No account, no email, no trial. | No sign-upWorks the moment the page loads. No account, no email, no trial. | No sign-upWorks the moment the page loads. No account, no email, no trial. |
| Your files | Runs on their server | Runs on their server | Runs on their server | Runs on their server |
| Where it stops | It cannot see your dose, your kidney function or your other conditions, so it flags possibilities for a pharmacist or doctor to judge — never stop or change a medicine on its say-so. | It is US foods with US portion conventions, and the branded entries are manufacturer-supplied rather than independently tested. | It is US-oriented reference material and deliberately general — it does not diagnose, and it is no substitute for seeing a clinician. | The interface is dated and search is weak, and some calculators and articles sit behind a paid Premium tier. |
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| Category | Health & Everyday Life | Health & Everyday Life | Health & Everyday Life | Health & Everyday Life |
| Last checked | 2026-07-29 | 2026-07-29 | 2026-07-29 | 2026-07-29 |
| Open the site | Open | Open | Open | Open |
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