say it: vis-IS-i-tood
vicissitude is a noun meaning "a variation in circumstances or fortune at different times in your life or in the development of something". It carries 2 recorded senses.
a variation in circumstances or fortune at different times in your life or in the development of something
“the project was subject to the usual vicissitudes of exploratory research”
mutability in life or nature (especially successive alternation from one condition to another)
Forms marked · are formed by the regular rule rather than recorded in the source data. English keeps a few hundred irregulars and the rest follow the pattern, so the rule is right far more often than not — but it is a rule, and the mark says so.
Definitions, synonyms and semantic relations for vicissitude come from Princeton University’s WordNet. The pronunciation comes from the CMU Pronouncing Dictionary. Commonness is measured against a corpus of everyday English. Full sources and licences.