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say it: MIS-iz
missis is a noun meaning "informal term of address for someone's wife". It is pronounced /ˈmɪsɪz/ — MIS-iz. It carries one recorded sense.
Forms marked · are formed by the regular rule rather than recorded in the source data. English keeps a few hundred irregulars and the rest follow the pattern, so the rule is right far more often than not — but it is a rule, and the mark says so.
Definitions, synonyms and semantic relations for missis come from Princeton University’s WordNet. The pronunciation comes from the CMU Pronouncing Dictionary. Commonness is measured against a corpus of everyday English. Full sources and licences.