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wise has 13 distinct synonyms spread across 5 of its 7 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is foolish.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
having or prompted by wisdom or discernment
“a wise leader”
United States Jewish leader (born in Hungary) (1874-1949)
United States religious leader (born in Bohemia) who united reform Jewish organizations in the United States (1819-1900)
Synonyms, antonyms and the broader and narrower relations for wise come from Princeton University’s WordNet. Full sources and licences.