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weaken has 11 distinct synonyms spread across 3 of its 5 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is strengthen.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
lessen the strength of
“The fever weakened his body”
destroy property or hinder normal operations
“The Resistance sabotaged railroad operations during the war”
reduce the level or intensity or size or scope of
“de-escalate a crisis”
Synonyms, antonyms and the broader and narrower relations for weaken come from Princeton University’s WordNet. Full sources and licences.