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uptown has no recorded synonym. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is downtown.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a residential part of town away from the central commercial district
of or located in the upper part of a town
“uptown residential areas”
Synonyms, antonyms and the broader and narrower relations for uptown come from Princeton University’s WordNet. Full sources and licences.
toward or in the upper part of town