uneasy has 7 distinct synonyms spread across 3 of its 5 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is easy.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
lacking a sense of security or affording no ease or reassurance
“farmers were uneasy until rain finally came”
socially uncomfortable; unsure and constrained in manner
“awkward and reserved at parties”
1 of the 5 recorded senses carries no synonym, antonym or related term, so it is not shown above. Every sense, with its definition and examples, is on the full entry for uneasy.
Synonyms, antonyms and the broader and narrower relations for uneasy come from Princeton University’s WordNet. Full sources and licences.