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substantial has 14 distinct synonyms spread across 6 of its 6 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is insubstantial.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
of or relating to the real nature or essential elements of something
“a substantial argument”
having substance or capable of being treated as fact; not imaginary
“the substantial world”
Synonyms, antonyms and the broader and narrower relations for substantial come from Princeton University’s WordNet. Full sources and licences.