spot has 37 distinct synonyms spread across 14 of its 20 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a point located with respect to surface features of some region
“this is a nice place for a picnic”
a short section or illustration (as between radio or tv programs or in a magazine) that is often used for advertising
an outstanding characteristic
“his acting was one of the high points of the movie”
a section of an entertainment that is assigned to a specific performer or performance
“they changed his spot on the program”
a business establishment for entertainment
“night spot”
a job in an organization
“he occupied a post in the treasury”
a small piece or quantity of something
“a spot of tea”
a playing card with a specified number of pips on it to indicate its value
“an eight-spot”
Synonyms, antonyms and the broader and narrower relations for spot come from Princeton University’s WordNet. Full sources and licences.