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side effect has 1 distinct synonym spread across 1 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a secondary and usually adverse effect of a drug or therapy
“severe headaches are one of the side effects of the drug”
any adverse and unwanted secondary effect
“a strategy to contain the fallout from the accounting scandal”
Synonyms, antonyms and the broader and narrower relations for side effect come from Princeton University’s WordNet. Full sources and licences.