setting has 9 distinct synonyms spread across 6 of its 7 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
the context and environment in which something is set
“the perfect setting for a ghost story”
the state of the environment in which a situation exists
“you can't do that in a university setting”
arrangement of scenery and properties to represent the place where a play or movie is enacted
the set of facts or circumstances that surround a situation or event
“the historical context”
the physical position of something
“he changed the setting on the thermostat”
a table service for one person
“a place setting of sterling flatware”
Synonyms, antonyms and the broader and narrower relations for setting come from Princeton University’s WordNet. Full sources and licences.