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sedate has 8 distinct synonyms spread across 3 of its 3 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is stimulate.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
characterized by dignity and propriety
cause to be calm or quiet as by administering a sedative to
“The patient must be sedated before the operation”
Synonyms, antonyms and the broader and narrower relations for sedate come from Princeton University’s WordNet. Full sources and licences.