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refined has 5 distinct synonyms spread across 3 of its 5 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is unrefined.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
(used of persons and their behavior) cultivated and genteel
“she was delicate and refined and unused to hardship”
1 of the 5 recorded senses carries no synonym, antonym or related term, so it is not shown above. Every sense, with its definition and examples, is on the full entry for refined.
Synonyms, antonyms and the broader and narrower relations for refined come from Princeton University’s WordNet. Full sources and licences.