profane has 19 distinct synonyms spread across 6 of its 6 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is sacred.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
not holy because unconsecrated or impure or defiled
grossly irreverent toward what is held to be sacred
“blasphemous rites of a witches' Sabbath”
corrupt morally or by intemperance or sensuality
“debauch the young people with wine and women”
Synonyms, antonyms and the broader and narrower relations for profane come from Princeton University’s WordNet. Full sources and licences.