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pill has 9 distinct synonyms spread across 2 of its 5 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
something that resembles a tablet of medicine in shape or size
a unpleasant or tiresome person
something unpleasant or offensive that must be tolerated or endured
“his competitor's success was a bitter pill to take”
a contraceptive in the form of a pill containing estrogen and progestin to inhibit ovulation and so prevent conception
Synonyms, antonyms and the broader and narrower relations for pill come from Princeton University’s WordNet. Full sources and licences.