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orient has 5 distinct synonyms spread across 5 of its 7 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is disorient.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
Synonyms, antonyms and the broader and narrower relations for orient come from Princeton University’s WordNet. Full sources and licences.
familiarize (someone) with new surroundings or circumstances
“The dean of students tries to orient the freshmen”
the hemisphere that includes Eurasia and Africa and Australia