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mainframe has 6 distinct synonyms spread across 2 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a large digital computer serving 100-400 users and occupying a special air-conditioned room
(computer science) the part of a computer (a microprocessor chip) that does most of the data processing
“the CPU and the memory form the central part of a computer to which the peripherals are attached”
Synonyms, antonyms and the broader and narrower relations for mainframe come from Princeton University’s WordNet. Full sources and licences.