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main has 6 distinct synonyms spread across 3 of its 5 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
(of a clause) capable of standing syntactically alone as a complete sentence
“the main (or independent) clause in a complex sentence has at least a subject and a verb”
a principal pipe in a system that distributes water or gas or electricity or that collects sewage
1 of the 5 recorded senses carries no synonym, antonym or related term, so it is not shown above. Every sense, with its definition and examples, is on the full entry for main.
Synonyms, antonyms and the broader and narrower relations for main come from Princeton University’s WordNet. Full sources and licences.