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lifeline has 2 distinct synonyms spread across 1 of its 4 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a crease on the palm; its length is said by palmists to indicate how long you will live
support that enables people to survive or to continue doing something (often by providing an essential connection)
“the airlift provided a lifeline for Berlin”
line that raises or lowers a deep-sea diver
line thrown from a vessel that people can cling to in order to save themselves from drowning
Synonyms, antonyms and the broader and narrower relations for lifeline come from Princeton University’s WordNet. Full sources and licences.