issue has 40 distinct synonyms spread across 14 of its 16 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is recall.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
an important question that is in dispute and must be settled
“the issue could be settled by requiring public education for everyone”
one of a series published periodically
“she found an old issue of the magazine in her dentist's waiting room”
some situation or event that is thought about
“he kept drifting off the topic”
the act of providing an item for general use or for official purposes (usually in quantity)
“a new issue of stamps”
supplies (as food or clothing or ammunition) issued by the government
a phenomenon that follows and is caused by some previous phenomenon
“the magnetic effect was greater when the rod was lengthwise”
the becoming visible
“not a day's difference between the emergence of the andrenas and the opening of the willow catkins”
Synonyms, antonyms and the broader and narrower relations for issue come from Princeton University’s WordNet. Full sources and licences.
circulate or distribute or equip with
“issue a new uniform to the children”
bring out an official document (such as a warrant)