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hopelessness has no recorded synonym. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is hopefulness.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
the despair you feel when you have abandoned hope of comfort or success
Synonyms, antonyms and the broader and narrower relations for hopelessness come from Princeton University’s WordNet. Full sources and licences.