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holy of holies has 1 distinct synonym spread across 1 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
(figurative) something regarded as sacred or inviolable
“every politician fears to touch that holy of holies, the Social Security System”
(Judaism) sanctuary comprised of the innermost chamber of the Tabernacle in the temple of Solomon where the Ark of the Covenant was kept
Synonyms, antonyms and the broader and narrower relations for holy of holies come from Princeton University’s WordNet. Full sources and licences.