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hole up has 1 distinct synonym spread across 1 of its 3 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
remain secluded or in hiding
“He is writing his book and is holing up in his study”
sleep during winter
“Bears must eat a lot of food before they hibernate in their caves”
Synonyms, antonyms and the broader and narrower relations for hole up come from Princeton University’s WordNet. Full sources and licences.