exhausted has 9 distinct synonyms spread across 2 of its 3 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is unexhausted.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
drained of energy or effectiveness; extremely tired; completely exhausted
“the day's shopping left her exhausted”
depleted of energy, force, or strength
“impossible to grow tobacco on the exhausted soil”
1 of the 3 recorded senses carries no synonym, antonym or related term, so it is not shown above. Every sense, with its definition and examples, is on the full entry for exhausted.
Synonyms, antonyms and the broader and narrower relations for exhausted come from Princeton University’s WordNet. Full sources and licences.