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distressed has 10 distinct synonyms spread across 4 of its 4 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
facing or experiencing financial trouble or difficulty
“distressed companies need loans and technical advice”
suffering severe physical strain or distress
“he dropped out of the race, clearly distressed and having difficulty breathing”
afflicted with or marked by anxious uneasiness or trouble or grief
“too upset to say anything”
Synonyms, antonyms and the broader and narrower relations for distressed come from Princeton University’s WordNet. Full sources and licences.