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depression has 9 distinct synonyms spread across 6 of its 10 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is elation.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a mental state characterized by a pessimistic sense of inadequacy and a despondent lack of activity
a long-term economic state characterized by unemployment and low prices and low levels of trade and investment
sad feelings of gloom and inadequacy
a period during the 1930s when there was a worldwide economic depression and mass unemployment
a state of depression and anhedonia so severe as to require clinical intervention
a concavity in a surface produced by pressing
“he left the impression of his fingers in the soft mud”
angular distance below the horizon (especially of a celestial object)
Synonyms, antonyms and the broader and narrower relations for depression come from Princeton University’s WordNet. Full sources and licences.