depressant has 3 distinct synonyms spread across 1 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is stimulative.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
a drug that reduces excitability and calms a person
Synonyms, antonyms and the broader and narrower relations for depressant come from Princeton University’s WordNet. Full sources and licences.
capable of depressing physiological or psychological activity or response by a chemical agent