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course of study has 7 distinct synonyms spread across 2 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
an integrated course of academic studies
“he was admitted to a new program at the university”
education imparted in a series of lessons or meetings
“he took a course in basket weaving”
Synonyms, antonyms and the broader and narrower relations for course of study come from Princeton University’s WordNet. Full sources and licences.