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colonize has 1 distinct synonym spread across 2 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is decolonize.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
settle as a colony; of countries in the developing world
“Europeans colonized Africa in the 17th century”
settle as colonists or establish a colony (in)
“The British colonized the East Coast”
Synonyms, antonyms and the broader and narrower relations for colonize come from Princeton University’s WordNet. Full sources and licences.