certain has 2 distinct synonyms spread across 5 of its 7 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is uncertain.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
established beyond doubt or question; definitely known
“what is certain is that every effect must have a cause”
exercising or taking care great enough to bring assurance
“be certain to disconnect the iron when you are through”
1 of the 7 recorded senses carries no synonym, antonym or related term, so it is not shown above. Every sense, with its definition and examples, is on the full entry for certain.
Synonyms, antonyms and the broader and narrower relations for certain come from Princeton University’s WordNet. Full sources and licences.