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activate has 9 distinct synonyms spread across 2 of its 5 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. Its one recorded opposite is inactivate.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
make active or more active
“activate an old file”
make more adsorptive
“activate a metal”
Synonyms, antonyms and the broader and narrower relations for activate come from Princeton University’s WordNet. Full sources and licences.