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run-down has 5 distinct synonyms spread across 1 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
1 of the 2 recorded senses carries no synonym, antonym or related term, so it is not shown above. Every sense, with its definition and examples, is on the full entry for run-down.
Synonyms, antonyms and the broader and narrower relations for run-down come from Princeton University’s WordNet. Full sources and licences.