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WordNet records no synonym and no antonym for quality of life. It is the only member of its synset, which is common for technical, taxonomic and single-sense vocabulary — there is no other English word that means the same thing. The broader and narrower terms below are the useful relations in that case.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
your personal satisfaction (or dissatisfaction) with the cultural or intellectual conditions under which you live (as distinct from material comfort)
“the new art museum is expected to improve the quality of life”
Synonyms, antonyms and the broader and narrower relations for quality of life come from Princeton University’s WordNet. Full sources and licences.