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WordNet records no synonym and no antonym for orthopnea. It is the only member of its synset, which is common for technical, taxonomic and single-sense vocabulary — there is no other English word that means the same thing. The broader and narrower terms below are the useful relations in that case.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
form of dyspnea in which the person can breathe comfortably only when standing or sitting erect; associated with asthma and emphysema and angina pectoris
Synonyms, antonyms and the broader and narrower relations for orthopnea come from Princeton University’s WordNet. Full sources and licences.