main street has 1 distinct synonym spread across 1 of its 2 senses. Each sense below keeps its own list, because a synonym belongs to a meaning and not to a word: swapping one sense's substitute into another sense's sentence is how a thesaurus makes writing worse. WordNet records no antonym for it — antonymy is a relation between word forms rather than concepts, so it is deliberately sparse.
Counts are distinct word forms across every sense. A synonym that appears under three senses is counted once here and shown three times below, under each sense it belongs to.
street that serves as a principal thoroughfare for traffic in a town
any small town (or the people who inhabit it); generally used to represent parochialism and materialism (after a novel by Sinclair Lewis)
“Main Street will never vote for a liberal politician”
Synonyms, antonyms and the broader and narrower relations for main street come from Princeton University’s WordNet. Full sources and licences.